Some medical professionals, though, are less eager to promote maintenance doses of semaglutide.
Dr. Katy Williams recently said that if major weight loss isn’t your goal, it may be more beneficial to make lifestyle changes first — like changes to diet and exercise habits — than to expose yourself to the potential side effects of GLP-1s, which range from nausea and dizziness to more severe cases like eating disorders, pancreatitis and thyroid cancer.
That being said, microdoses do have key differences from standard doses. For example, it’s likely they won’t lead to the same dramatic decrease in appetite. But ultimately, they need to be studied more.
“The intent here is to have some therapeutic effects,” Aziz said. Based on the information we have now, it’s possible that small doses could help address inflammation, what he calls “a hallmark of aging.”
2. Epitalon
Another hallmark of aging? Shortened telomeres.
“As the cells divide, your telomeres — the end caps of chromosomes — get shorter and shorter,” Aziz explained. “And eventually there is no more cell division, and there’s cell death. So longer telomeres mean longer life. Shorter telomeres means shorter life.”
He added that epitalon is a peptide that few doctors know about, but one that’s been developed to counteract this very process. By activating a specific enzyme, it lengthens telomeres, which is thought to delay cellular aging.
In one study on the effects of epitalon on rat cells, the peptide “induced the active proliferation of the cultured cells.” Another study, this time on human fetal tissue, found that epitalon-treated cells “demonstrated high telomere lengths,” which led the authors to believe that epitalon has some anti-aging capacities. The treated cells continued dividing long after the untreated cells stopped.
And while epitalon needs significantly more study on human subjects, Aziz insisted on its multitude of benefits. “It improves sleep, skin health and appearance as an antioxidant,” he said. “It heals injuries and prevents some age-related diseases like cancer, heart disease and dementia.”
3. GHK-Cu
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My 9-year-old daughter baked 300 Easter cookies for the homeless — the next morning, a stranger showed up at our door with a briefcase full of cash. My daughter, Ashley, has always had a heart too big for her chest. Since my wife died, we’ve barely been making ends meet. We spent everything we had trying to save her from cancer. But when Easter came this year, Ashley told me she’d been saving up her own money to buy ingredients. “For the homeless,” she said. Her mom used to be one of them. She was thrown out by her parents when they found out she was pregnant with Ashley. When I met her, she had nothing — but she had the brightest smile and the sharpest mind I had ever seen. I fell in love with her. I took her and Ashley in. And from that moment on, Ashley became my daughter in every way that matters. So when Ashley said she wanted to help people like her mom once was… I didn’t stop her. For three nights straight, after school and homework, she baked. Her little hands worked nonstop. She found her mom’s old cookie recipe. She rolled every piece of dough herself. She decorated every cookie. She made three hundred cookies. On Easter, she handed them out one by one. She looked people in the eyes. She wished them a Happy Easter. Some of them smiled. Some of them cried. I stood there thinking it was the proudest moment of my life. I thought that was the end of it. The next morning, I was washing a mountain of dishes when the doorbell rang. I opened the door. An older man stood there in a worn-out suit, holding a scratched aluminum briefcase. His eyes were locked on Ashley. Before I could ask anything, he set the case down and opened it. I froze. Stacks of hundred-dollar bills — more money than I had ever seen in my life. “I saw what your daughter did yesterday,” he said, his voice shaking. “I want to give all of this to her.” My heart skipped. Then he added: “But you have to agree to ONE CONDITION.” My chest tightened. “What condition?” I asked. He stepped closer. He lowered his voice. And what he asked for in return made my blood run cold.
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